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Benninga 2016 Rome IV G4 infant colic (clinical). rome_iv_infant_colic is true iff the infant is less than 5 months of age when symptoms start and stop, recurrent prolonged crying, fussing, or irritability without obvious cause that caregivers cannot prevent or resolve, and no evidence of failure to thrive, fever, or illness. Research 3-hour/diary criteria are not parsed. Caller assigns three flags. magent does not examine the infant. Not a diagnosis.